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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
Christopher A. Lipinski, Franco Lombardo, Beryl W. Dominy, Paul J. Feeney - Advanced Drug Delivery Reviews - 1997该记录暂无摘要，您可以通过来源链接查看详细信息。被引用次数：10,941Natural products in drug discovery: advances and opportunities
Atanas G. Atanasov, Sergey B. Zotchev, Verena M. Dirsch, İlkay Erdoğan Orhan - Nature Reviews Drug Discovery - 2021该记录暂无摘要，您可以通过来源链接查看详细信息。被引用次数：4,580Network pharmacology: the next paradigm in drug discovery
Andrew L. Hopkins - Nature Chemical Biology - 2008该记录暂无摘要，您可以通过来源链接查看详细信息。被引用次数：4,165ChEMBL: a large-scale bioactivity database for drug discovery
Anna Gaulton, Louisa J. Bellis, A. Patrícia Bento, Jon Chambers - Nucleic Acids Research - 2011ChEMBL is an Open Data database containing binding, functional and ADMET information for a large number of drug-like bioactive compounds. These data are manually abstracted from the primary published literature on a regular basis, then further curated and standardized to maximize their quality and utility across a wide range of chemical biology and drug-discovery research problems. Currently, the database contains 5.…被引用次数：4,260LigPlot+: Multiple Ligand–Protein Interaction Diagrams for Drug Discovery
Roman A. Laskowski, Mark B. Swindells - Journal of Chemical Information and Modeling - 2011We describe a graphical system for automatically generating multiple 2D diagrams of ligand-protein interactions from 3D coordinates. The diagrams portray the hydrogen-bond interaction patterns and hydrophobic contacts between the ligand(s) and the main-chain or side-chain elements of the protein. The system is able to plot, in the same orientation, related sets of ligand-protein interactions. This facilitates popular…被引用次数：6,230TCMSP: a database of systems pharmacology for drug discovery from herbal medicines
Jinlong Ru, Peng Li, Jinan Wang, Wei Zhou - Journal of Cheminformatics - 2014该记录暂无摘要，您可以通过来源链接查看详细信息。被引用次数：4,791Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1
Christopher A. Lipinski, Franco Lombardo, Beryl W. Dominy, Paul J. Feeney - Advanced Drug Delivery Reviews - 2001该记录暂无摘要，您可以通过来源链接查看详细信息。被引用次数：17,512Principles of early drug discovery
J. P. HUGHES, S. Rees, S. Barret Kalindjian, K.L. Philpott - British Journal of Pharmacology - 2010Developing a new drug from original idea to the launch of a finished product is a complex process which can take 12–15 years and cost in excess of $1 billion. The idea for a target can come from a variety of sources including academic and clinical research and from the commercial sector. It may take many years to build up a body of supporting evidence before selecting a target for a costly drug discovery programme. O…被引用次数：2,683Drug Discovery: A Historical Perspective
Jürgen Drews - Science - 2000Driven by chemistry but increasingly guided by pharmacology and the clinical sciences, drug research has contributed more to the progress of medicine during the past century than any other scientific factor. The advent of molecular biology and, in particular, of genomic sciences is having a deep impact on drug discovery. Recombinant proteins and monoclonal antibodies have greatly enriched our therapeutic armamentariu…被引用次数：2,725DrugBank: a comprehensive resource for in silico drug discovery and exploration
David S. Wishart - Nucleic Acids Research - 2005DrugBank is a unique bioinformatics/cheminformatics resource that combines detailed drug (i.e. chemical) data with comprehensive drug target (i.e. protein) information. The database contains >4100 drug entries including >800 FDA approved small molecule and biotech drugs as well as >3200 experimental drugs. Additionally, >14,000 protein or drug target sequences are linked to these drug entries. Each DrugCard entry con…被引用次数：3,949